Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies and Estimates (Details 3)

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Summary of Significant Accounting Policies and Estimates (Details 3) - shares
shares in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities 4,440 5,802 3,513
Options to purchase common stock [Member]      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities 2,477 1,963 1,542
Warrants for common stock [Member]      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities 1,963 1,963 1,971
Common stock issuable upon conversion of preferred shares [Member]      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities 0 1,876 0