Annual report pursuant to Section 13 and 15(d)

Income Taxes - Narrative (Details)

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Income Taxes - Narrative (Details) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Examination [Line Items]    
Current federal and state income tax expense (benefit) $ 0 $ 0
Deferred federal and state income tax expense (benefit) 0 0
Increase (decrease) in valuation allowance 4,587,000 $ 3,192,000
Federal    
Income Tax Examination [Line Items]    
Operating loss carryforwards 176,926,000  
Federal | Research and development tax credit    
Income Tax Examination [Line Items]    
Operating loss carryforwards 1,997,000  
State    
Income Tax Examination [Line Items]    
Operating loss carryforwards 114,741,000  
State | Research and development tax credit    
Income Tax Examination [Line Items]    
Operating loss carryforwards 677,000  
Foreign    
Income Tax Examination [Line Items]    
Operating loss carryforwards 10,350,000  
Generated before 2018, expire 2027 | Federal    
Income Tax Examination [Line Items]    
Operating loss carryforwards 120,792,000  
Generated before 2018, carryforward indefinitely | Federal    
Income Tax Examination [Line Items]    
Operating loss carryforwards $ 56,134,000